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While CCs volatilize nicotine through tobacco combustion at temperatures around 700C, HnB heats ground tobacco that is reconstituted into sheets through contact with a metal blade as a heating element or a heating chamber where tobacco sticks are placed inside the device, and external resistive heaters made of stainless-steel tracks (Vivarelli et al., 2022)

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Researchers also did not include female mice in the study, further limiting the data

doi:10.1056/nejmicm1312190 13Pandey N, John S